Occupational exposure to formaldehyde: the proposal of Lombardy region





Formaldehyde, Occupational Exposure, Risk Management


Formaldehyde is a chemical agent with peculiar toxicological properties; due to its diffusion in several industrial fields, its wide use in healthcare sector and its ubiquitous presence in general environments (as a product of materials’ emissions and/or photochemical reactions), formaldehyde constitutes a very common risk agent in the living and working environments. By Regulation (EU)  895/2014, formaldehyde has been classified as a category 1B carcinogen. This led to the need to consider carcinogenic risk management of the exposed worker. The Lombardy Region has provided guidelines for the management of occupational exposure risk to formaldehyde, with the aim of defining a correct framework for the problem and providing operational guidance to ensure a uniform approach in the territory. This guideline, therefore, proposes indications on the technical and organizational preventive interventions to be taken to risk assessment and management.


- American Conference of Governmental Industrial Hygienists (ACGIH), Documentation of the Threshold Limit Values and Biological Exposure Indices, 7th Edition - 2017.

- Atkinson R., Arey J. 2003. Gas-phase tropospheric chemistry of biogenic volatile organic compounds: a review. Atmos. Environ. 37(suppl 2): S197-S219.

- Beane Freeman, L.E., Blair, A., Lubin, J. H., Stewart, P.A., Hayes, R.B., Hoover, R.N., Hauptmann, M. 2013. Mortality from solid tumors among workers in formaldehyde industries: an update of the NCI cohort. Am. J. Ind. Med., 56(9), 1015-1026.

- De palma G., MAdeo E., Cavallo D.M., Carrieri M., Leghissa P., Mattioli S., Mutti A., Romano C., Scapellato M.L. Spatari G., Apostoli P. 2017. Linee guida sulla caratterizzazione e gestione del rischio e sulla sorveglianza sanitaria in lavoratori professionalmente esposti a formaldeide. G. Ital. Med. Lav. Erg., 39 (3, Suppl), 36-37.

- Fiocca R., Marchetti A., Massi D., Truini M., Zanin T. 2, 016.Note relative all’utilizzo della formalina, ri-classificata “cancerogena†- Linee di indirizzo SIAPEC-IAP Divisione Italiana.

- International Agency for Research on Cancer (IARC). 2012. Formaldehyde. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 100F. IARC, Lyon 2012. http:// onographs.iarc.fr/ENG/Monographs/vol100F/index.php.

- Kerns, W. D., Pavkov, K. L., Donofrio, D. J., Gralla, E. J., Swenberg, J. A. 1983. Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res., 43(9), 4382-4392.

- Lang, I., Bruckner, T., & Triebig, G. 2008. Formaldehyde and chemosensory irritation in humans: a controlled human exposure study. Regul. Toxicol. Pharmacol., 50(1), 23-36.

- Ministero della Salute, Consiglio Superiore di Sanità . Linee Guida: Tracciabilità , Raccolta, Trasporto, conservazione e Archiviazione di cellule e tessuti per indagini diagnostiche di Anatomia Patologica. Maggio 2015. Disponibile online http://www.salute.gov.it/imgs/C_17_pubblicazioni_2369_allegato.pdf

- Monticello, T. M., Swenberg, J. A., Gross, E. A., Leininger, J. R., Kimbell, J. S., Seilkop, S., Starr, T. B., Gibson, J. E., and Morgan K. T. 1996. Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells. Cancer Res. 56, 1012–1022.

- Nielsen, G. D., Larsen, S. T., & Wolkoff, P. 2017. Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment. Arch. Toxicol., 91(1), 35-61.

- Regione Lombardia, Direzione Generale Welfare. Linea guida regionale sulla stima e gestione del rischio da esposizione a formaldeide: razionalizzazione del problema e proposta operativa. Decreto n. 11665 del 15/11/2016.

- Salthammer T., Mentese S., Marutzky R. 2010. Formaldehyde in the indoor environment. Chem. Rev 110:2536-2572

Sarigiannis D.A., Karakitsios S.P., Gotti A., Liakos I.L., Katsoyiannis A. 2011. Exposure to major volatile organic compounds and carbonyls in European indoor environments and associated health risk. Environ. Int. 37:743-765.

- Scientific Committee on Occupational Exposure Limits (SCOEL), Recommendation from the Scientific Committee on Occupational Exposure Limits – Formaldehyde - SCOEL/REC/125, Brussels, 2016.

- Wolkoff, P. 2013. Indoor air pollutants in office environments: assessment of comfort, health, and performance. Int. J. Hyg. Environ. Health., 216(4), 371-394.

- World Health Organization (WHO. 2010. Formaldehyde. In: Selected pollutants. WHO Guidelines for Indoor Air Quality. WHO, Regional Office for Europe, Copenhagen, Denmark, pp 103-156. ISBN 978 92 890 02134