Cumulative lead exposure, blood pressure, and pulse pressure: a longitudinal case-control study.

Ziadi Boukerma, Ahmed-Lakhdar Behlouli, Ammar Terra


Background: The action of lead on blood pressure is always subject to discussion. To this, is added the possible action of the lead on the pulse pressure. Objective: To evaluate the effect of lead on blood pressure and pulse pressure by a longitudinal case-control study (275 exposed people and 282 controls). Method: The studied parameters of this study came from the medical follow-up records of the workers. Multivariate analyses and the study of survival time are made by SPSS version 20 software. Results: mean systolic and diastolic pressures were significantly higher (p < 0.000) in lead-exposed workers than in controls. Ditto for pulsed pressure (p < 0.000). There are almost two times more systolic and diastolic hypertension in lead-exposed workers. Survival was significantly much lower in the exposed cohort. Conclusion: The average lead as well as the cumulative lead act both on the pressure parameters.


Blood pressure, pulse pressure, blood lead, cumulative blood lead, lead exposure.

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