Human exposure assessment in the framework of European chemicals control legislation REACH: from industrial hygiene to exposure science

Ian Urbanus


The European chemicals control regulation REACH requires quantitative assessment to demonstrate that worker inhalation and dermal exposure levels remain below toxicological reference values (Derived No Effect Levels) during the entire life cycle of a chemical. This has stimulated the development of a new and efficient approach that allows focus on potentially problematic chemical applications, whilst providing reasonable assurance that exposure in less challenging conditions is of no concern. The approach was necessary to deal with a very large number of exposure scenarios in a comparatively short time-frame and emerged from a process of simplification and standardization building on industrial hygiene knowledge of worker exposure determinants and good practice recommendations for exposure control.


REACH, DNEL, exposure scenarios

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Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC

European Chemicals Agency (2016). Guidance on Information Requirements and Chemical Safety Assessment. Chapter R.14: Occupational exposure assessment, Version 3.0

Money, C.; A. Margary; D. Noij and K. Hommes (2011): Generic Exposure Scenarios: Their development, application and interpretation under REACH. Ann Occup Hyg 55(5): 451-464

European Centre of Ecotoxicology and Toxicology of Chemicals (ECETOC) (2012). ECETOC TRA version 3: Background and Rationale for Improvements. Technical Report 114, available from:

European Centre of Ecotoxicology and Toxicology of Chemicals (ECETOC) (2014). Addendum to TR114: Technical Basis for the TRA v3.1. Technical Report 124, available from:

Money, C.; F. Schnoeder; D. Noij; HY Chang and J. Urbanus (2014). ECETOC TRA Version 3: Capturing and consolidating the experiences of REACH. Environ Sci Process Impacts 16(5): 970-7

Tielemans E, Warren N, Fransman W, et al. (2011). Advanced REACH Tool (ART): overview of version 1.0 and research needs. Ann Occup Hyg; 55: 949–56

Schinkel J, Ritchie P, Goede H, et al. (2013). The Advanced REACH Tool (ART): incorporation of an exposure measurement database. Ann Occup Hyg; 57: 717–27

Landberg H, Berg P, Andersson L, and Bergendorf U (2015). Comparison and Evaluation of Mulitple Users’ Usage of the Epxosure and risk tool: Stoffenmanager 5.1. Ann Occup Hyg; 59: 821–35

Galea K, Davis A, Todd D, et al. (2014). Dermal exposure from transfer of lubricants and fuel by consumers. Journal of Exposure Science and Environmental Epidemiology 24: 665 – 72

CONCAWE (2014). Dermal exposures associated with service station refuelling activities: preliminary evaluation. Report 14/14, available from:

Christopher Y, van Tongeren M, Urbanus J and Cherrie J (2011). An assessment of dermal exposure to Heavy Fuel Oil (HFO) in occupational settings. Ann. Occup. Hyg., Vol. 55: 319–328

European Solvents Industry Group (2015). ESIG Risk Management Measures (RMM) Project, executive summary. Available from:

CONCAWE (2012). Developing human health exposure scenarios for petroleum substances under REACH. Report 11/12, available from:

CONCAWE (2015). Monitoring method for exposure to gas oil vapour and aerosol. Report 8/15, available from:


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