Engineered nanomaterials: current status of occupational exposure assessment.

Andrea Spinazzè, Andrea Cattaneo, Luca Del Buono, Luca Fontana, Ivo Iavicoli, Domenico Maria Cavallo


An increasing number of studies are indicating that the health risk deriving from exposure to engineered nanomaterials (ENMs) and nanoparticles (ENPs) is not adequately addressed by conventional exposure evaluation methods and strategies. The global aim of this study was to carry out a review of the state-of-the-science of ENMs occupational exposure assessment, with particular concern on the main problems related to ENPs exposure assessment. Original articles and reviews in principal databases of scientific literature were included in this paper; grey literature (released by qualified regulatory agencies and scientific organizations) was also taken into consideration. The paper discusses in particular the main problems found in ENPs exposure assessment, which have been generally identified in: (i) the choice of a proper dosimetric for exposure assessment, (ii) the lack of adequate and reliable measurement techniques, (iii) the need of a harmonized monitoring strategy, (iv) the need of an effective method for the distinction of ENPs from background particles and (v) the difficulties to compare ENPs exposure data with proper Occupational Exposure Limits. On the basis of the considered existing approaches, some key issues related to exposure assessment strategies, derived from direct on-field exposure are then discussed, as well as some identified priorities in the field of ENPs exposure assessment. In conclusion, most of the existing techniques and strategies for occupational exposure assessment to ENPs and ENMs require adjustment, and significant methodological gaps need to be reduced. The rational use of risk management strategies and the application of specifically-developed Occupational Exposure Limits are crucial to mitigate the risk posed for ENP-exposed workers. The development and harmonization of appropriate exposure assessment strategies and techniques and risk management approaches represent an essential step toward developing health and safety standards for ENP.


Engineered nanomaterials; Engineered nanoparticles; risk management; exposure assessment

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Author 1 et al., 2016a

Author 1 et al., 2016b

Author 2 et al., 2016

Author 2 et al., 2014

Author 2 et al., 2013a

Author 2 et al., 2013b

Author 2 et al., 2012

Author 2 et al., 2011

Author 3 et al., 2010

Aalto, P., Hämeri, K., Paatero, P., et al., 2002. Aerosol particle number concentration measurements in five European cities using TSI-3022 condensation particle counter over a three-year period during health effects of air pollution on susceptible subpopulations J. Air. Waste. Manage. Assoc. 55,1064-1076.

Abbott, L.C., Maynard, A.D., 2010. Exposure assessment approaches for engineered nanomaterials. Risk Analysis 30(11),1634-1644.

Aitken, R.J., Hankin, S.M., Ross, B., et al., 2009. EMERGNANO: A review of completed and near completed environment, health and safety research on nanomaterials and nanotechnology. Defra Project CB0409. Edinburgh, UK, Institute of Occupational Medicine.

Asbach, C., Kaminski, H., Fissan, H., et al, 2009. Comparison of four mobility particle sizers with different time resolution for stationary measurement. J. Nanopart. Res. 11,1593-1609

Asbach, C., Kaminski, H., Von Barany, D., et al., 2012a. Comparability of Portable Nanoparticle Exposure Monitors. Ann. Occ. Hyg. 56(5),606-621.

Asbach, C., Kuhlbusch, T., Kaminski, H., et al., 2012b. NanoGEM standard operation procedures for assessing exposure to nanomaterials, following a tiered approach.

Balbus, J.M., Florini, K., Denison, R.A., Walsh, S.A., 2007. Protecting workers and the environment, An environmental NGO’s perspective on nanotechnology. J. Nanopart. Res. 9(1),11-22.

Beck-Speier, I., Dayal, N., Karg, E., et al., 2001. Agglomerates of ultrafine particles of elemental carbon and TiO2 induce generation of lipid mediators in alveolar macrophages. Environ. Health. Perspect. 109,613-618.

Berges, M.G.M. Exposure during Production and Handling of Manufactured Nanomaterials. In Nanomaterials (ed Deutsche Forschungsgemeinschaft (DFG)), Wiley-VCH Verlag. GmbH & Co. KGaA, Weinheim, (Germany), 2013.

Berges, M.G.M., Aitken, R.J., Read, S.A.K., et al. Risk Assessment and Risk Management. In Handbook of Nanosafety - Measurement, Exposure & Toxicology, Elsevier Academic Press, London (UK), 2014.

Borm, P.J., Robbins, D., Haubold, S., 2006. The potential risks of nanomaterials: a review carried out for ECETOC. Part. Fibre Toxicol. 14(3),11.

Borm, P.J., Kreyling, W., 2004. Toxicological hazards of inhaled nanoparticles. Potential implications for drug delivery. J. Nanosci. Nanotechnol. 4,521-531.

Brouwer, D.H., Gijsbers, J.H., Lurvink, M.W., 2004. Personal exposure to ultrafine particles in the workplace: exploring sampling techniques and strategies. Ann. Occup., Hyg. 48(5),439-453.

Brouwer, D.H., van Duuren-Stuurman, B., Berges, M., et al., 2009. From workplace air measurement results towards estimates of exposure? Development of a strategy to assess exposure to manufactured nano-objects. J. Nanopart. Res. 11,1867-1881.

Brouwer, D.H., 2010. Exposure to manufactured nanoparticles in different workplaces. Toxicology 269,120-127.

Brouwer, D.H., Berges, M.G.M., Virji, M.A., et al., 2012. Harmonization of measurement strategies for exposure to manufactured nano-objects; report of a workshop. Ann. Occup. Hyg. 56(1),1-9.

Brown, D.M., Wilson, M.R., MacNee, W., et al., 2001. Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines particles. Toxicol. Appl. Pharmacol. 175(3),191-199.

Card, J.W., Zeldin, D.C., Bonner, J.C., Nestmann, E.R., 2008. Pulmonary applications and toxicity of engineered nanoparticles. Am. J. Physiol. Lung Cell. Mol. Physiol. 295(3),L400-L411.

Cassee, F.R., Héroux, M.E., Gerlofs-Nijland, M.E., Kelly, F.J., 2013. Particulate matter beyond mass: recent health evidence on the role of fractions, chemical constituents and sources of emission. Inhal. Toxicol. 25(14),802-812.

Commission of the European Communities COM (2000) 1: Communication from the Commission on the precautionary principle Communication from the Commission to the European Parliament, the Council and the European Economic and Social Committee. Regulatory aspects of nanomaterials (Sec(2008) 2036)

Consensus Report: Tiered approach to an exposure measurement and assessment of nanoscale aerosols released from engineered nanomaterials in workplace operations, BAuA, BGRCI, IFA and VCI, Germany. 2011

Cornelissen, R., Jongeneelen, F., van Broekhuizen, P., et al., 2012. Guidance working safely with nanomaterials and - products, the guide for employers and employees. FNV, VNO/NCW, CNV.

Council Directive 98/24/EC of 7 April 1998 on the protection of the health and safety of workers from the risks related to chemical agents at work.

Council Directive of 12 June 1989 on the introduction of measures to encourage improvements in the safety and health of workers (89/391 EEC), OJL 183, 29 June 1989.

Crosera, M., Bovenzi, M., Maina, G., et al., 2009. Nanoparticle dermal absorption and toxicity: a review of the literature. Int. Arch. Occup. Environ. Health. 82(9),1043-1055.

Daigle, C.C., Chalupa, D.C., Gibb, F.R., et al,. 2003. Ultrafine particle deposition in humans during rest and exercise. Inhal Toxicol 15(6),539-552.

Donaldson, K., Beswick, P.H., Gilmour, P.S., 1996. Free radical activity associated with the surface of particles: a unifying factor in determining biological activity? Toxicol. Lett. 88(1),293-298.

Donaldson, K., Duffin, R., Langrish, J.P., et al., 2013. Nanoparticles and the cardiovascular system: a critical review. Nanomedicine (Lond). 8(3),403-423.

Donaldson, K., Stone, V., Clouter, A., et al., 2001. Ultrafine particles. Occ. Environ. Med. 58(3),211-216.

Donaldson, K., Stone, V., Gilmour, P.S., et al., 2000. Ultrafine particles: mechanisms of lung injury. Philos. Trans. Roy. Soc. London Ser. A 358(1775), 2741-2749.

EU-OSHA (2013) E-fact 72: Tools for the management of nanomaterials in the workplace and prevention measures.

European committee for Standardization

(CEN), European Committee for Standardisation (CEN). (1995) EN 689:1995 Workplace atmospheres - guidance for the assessment of exposure by inhalation to chemical agents for comparison with limit values and measurement strategy. Bruxelles, Belgium: European committee for Standardization (CEN).

CEN, European Committee for Standardisation (CEN). (1993). EN 481:1993 Workplace atmospheres – Size fraction definitions for measurement of airborne particles. Bruxelles, Belgium: European committee for Standardization (CEN).

European Parliament and Council Directive 2004/37/EC on the protection of workers from the risks related to exposure to carcinogens or mutagens at work.

Feng, X., Chen, A., Zhang, Y., Wang, J., Shao, L., Wei, L., 2015. Central nervous system toxicity of metallic nanoparticles. Int. J. Nanomedicine. 10,4321-4340.

Fierz, M., Burtscher, H., Steigmeier, P., Kasper, M., 2008. Field Measurement of Particle Size and Number Concentration with the Diffusion Size Classifier (DiSC). SAE Technical Paper 01-1179

Fierz, M., Houle, C., Steigmeier, P., Burtscher, H., 2011. Design, calibration, and field performance of a miniature diffusion size classifier. Aerosol. Sci. Tech. 45(1),1-10.

Fierz, M., Meier, D., Steigmeier, P., Burtscher, H., 2014. Aerosol measurement by induced currents. Aerosol. Sci. Technol. 48(4),350-357.

Flagan, R.C. Electrical techniques. In Baron PA and Willeke K (eds): Aerosol measurement: principles, techniques and applications. John Wiley &Sons, New York (USA), 2001.

GAO-14-181SP, 2014. United States Government Accountability Office (GAO): Nanomanufacturing. Emergence and Implications for U.S. Competitiveness, the Environment, and Human Health.

Hamoir, J., Nemmar, A., Halloy, D., et al., 2003. Effect of polystyrene particles on lung microvascular permeability in isolated perfused rabbit lungs: role of size and surface properties. Toxicol. App. Pharmacol. 190(3),278-285.

Heim, M., Mullins, B.J., Umhauer, H., Kasper, G. 2008. Performance evaluation of three optical particle counters with an efficient “multimodal” calibration method. J. Aerosol. Sci. 39(12),1019-1031

Hind, W.C. Aerosol Technology: Properties, Behavior, and Measurement of airborne particles. Second edition, 2nd ed. Wiley-Interscience, New York (USA), 1999

Hofmann, W., Sturm, R., Winkler-Heil, R., Pawlak, E., 2003. Stochastic model of ultrafine particle deposition and clearance in the human respiratory tract. Radiat. Prot. Dosim.105(1-4),77-79.

ICRP, International Commission on Radiological Protection, 1994. Publication 66: Human respiratory tract model for radiological protection. Pergamon, Elsevier Science Ltd, Oxford.

International Organization for Standardization (1995)

International Standardization Organisation. Air Quality – Particle size fraction definitions for health-related sampling, ISO 7708:1995

International Standardization Organisation (2007). Workplace atmospheres - Ultrafine, nanoparticle and nano-structured aerosols - Inhalation exposure characterization and assessment. Technical Report ISO/TR 27628/2007

International Organization for Standardization (2008) Nanotechnologies-terminology and definitions for nano-objects, nanoparticle, nanofibre and nanoplate ISO TS 27687. Geneva, Switzerland: International Organization for Standardization.

International Organization for Standardization (2008) Health and Safety Practices in Occupational Settings Relevant to Nanotechnologies, ISO Document No. ISO/ TR ISO/TR 12885:2008(E). Geneva, Switzerland.

Jaques, P.A., Kim, C.S., 2000. Measurement of total lung deposition of inhaled ultrafine particles in healthy men and women. Inhal. Toxicol. 12(8),715-731.

Jensen, A.C.Ø.; Levin, M.; Koivisto, A.J.; et al., 2015. Exposure assessment of particulate matter from abrasive treatment of carbon and glass fibre-reinforced epoxy-composites - Two case studies. Aerosol Air Qual. Res. 15(5), 1906-1916.

Johnson, R.L., 2004. Relative effects of air pollution on lungs and heart. Circulation, 109(1),5-7.

Kaluza, S., Balderhaar, J.K., Orthen, B., et al., 20009. Literature Review-Workplace Exposure to Nanoparticles, Kosk-Bienko J, ed. Spain: European Agency for Safety and Health at Work (EU-OSHA) 1-89.

Kaminski, H., Kuhlbusch, T.A., Rath, S., et al., 2013. Comparability of mobility particle sizers and diffusion chargers. J. Aerosol. Sci. 57,156-178.

Keller, A., Fierz, M., Siegmann, K., et al., 2001. Surface science with nanosized particles in a carrier gas. J. Vacuum. Sci. Technol. 19(1),1-8.

Kim, S., Shen, S., Sioutas, C., et al., 2002. Size distribution and diurnal and seasonal trends of ultrafine particles in source and receptor sites of the Los Angeles Basin. J. Air. Waste. Manage. Assoc. 52,297-307

Koivisto, A.J.; Jensen, A.C.Ø.; et al., 2015. Testing a Near Field/Far Field model performance for prediction of particulate matter emissions in a paint factory. Environ. Sci. Process. Impacts. 17,62-73.

Koivisto, A.J.; Palomäki, J.E.; Viitanen, A-K.; et al., 2014. Range-Finding Risk Assessment of Inhalation Exposure to Nanodiamonds in a Laboratory Environment. Int J Environ Res Public Health 11,5382-5402.

Koivisto, A.J.; Aromaa, M.; Mäkelä, et al., 2012a. Concept to estimate regional inhalation dose of industrially synthesized nanoparticles. ACS Nano 6,1195-1203.

Koivisto, A.J.; Lyyränen, J.; Auvinen, et al. (2012b) Industrial worker exposure to airborne particles during the packing of pigment and nanoscale titanium dioxide. Inhal. Toxicol. 24,839-849.

Koponen, I.K.; Koivisto, A.J.; Jensen, K.A., 2015. Worker exposure and high time-resolution analyses of process-related dust concentrations at mixing stations in two paint factories. Annals of Occupational Hygiene. Advance Article, doi:10.1093/annhyg/mev014.

Kreyling, W.G., Semmler, M., Erbe, F., et al., 2002. Translocation of ultrafine insoluble iridium particles from lung epithelium to extra-pulmonary organs is size dependent but very low. J. Toxicol. Environ. Health. 65(20),1513-1530.

Kuhlbusch, T.A.J., Asbach, C., Fisaan, H., et al., 2011. Nanoparticle exposure at nanotechnology workplaces: A review. Part. Fibre. Toxicol. 8(22),1-18.

Larese Filon, F., D’Agostin, F., Crosera, M., et al., 2009. Human skin penetration of silver nanoparticles through intact and damaged skin. Toxicol. 255,33-37

Larese Filon, F., Mauro, M., Adami, G., et al., 2015. Nanoparticles skin absorption: New aspects for a safety profile evaluation. Regul. Toxicol. Pharmacol. 72(2),310-322

Levin, M., Witschger, O., Bau, S., et al., 2015. Can We Trust Real Time Measurements of Lung Deposited Surface Area Concentrations in Dust from Powder Nanomaterials? Aerosol Air Qual. Res. doi: 10.4209/aaqr.2015.06.0413 (Article in press).

Li, N., Sioutas, C., Cho, A., et al., 2003. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ. Health. Persp. 111(4),455.

Lison. D., Lardot, C., Huaux, F., et al., 1997. Influence of particle surface area on the toxicity of insoluble manganese dioxide dusts. Arch. Toxicol. 71(12),725-729.

Liu, Y., Beaucham, C.C., Pearce, T.A., Zhuang, Z., 2014. Assessment of Two Portable Real-Time Particle Monitors Used in Nanomaterial Workplace Exposure Evaluations. PLoS ONE 9(8), e105769 doi:10.1371/journal.pone.0105769.

Lu, X., Zhu, T., Chen, C., Liu, Y., 2014. Right or left: the role of nanoparticles in pulmonary diseases. Int. J. Mol. Sci. 15(10),17577-17600.

Ma, T., Wang, L., Yang, T., Ma, G., Wang, S., 2014. M-cell targeted polymeric lipid nanoparticles containing a toll-like receptor agonist to boost oral immunity. Int. J. Pharm. 473(1-2),296–303.

Marconi, A., Cattani, G., Cusano, M., et al., 2007. Two years of fine and ultrafine particles measurements in Rome, Italy. J. Toxicol. Environ. Health. A 70,213-221.

Marjamäki, M., Keskinen, J., Chen, D.R., Pui, D.Y., 2000. Performance evaluation of the electrical low-pressure impactor (ELPI). J. Aerosol Sci. 31(2),249-261.

Maynard, A.D., Aitken, R.J., 2007. Assessing exposure to airborne nanomaterials; current abilities and future requirements. Nanotoxicology 1,26-41

Methner, M., Hodson, L., & Geraci, C. 2009. Nanoparticle emission assessment technique (NEAT) for the identification and measurement of potential inhalation exposure to engineered nanomaterials-Part A. J Occ. Environ. Hyg 7(3), 127-132.

Methner, M., Hodson, L., Dames, A., Geraci, C., 2010. Nanoparticle Emission Assessment Technique (NEAT) for the identification and measurement of potential inhalation exposure to engineered nanomaterials--Part B: Results from 12 field studies. J. Occ. Environ. Hyg. 7(3), 163-176.

Mirer, F.E., Stellman, J.M. Occupational safety and health protections. In Heggenhougen K, Quah SR (eds): International encyclopedia of public health. Elsevier Academic Press, Oxford (UK), 2008.

Monteiller, C., Tran, L., MacNee, W., et al., 2007. The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area. J. Occup. Env. Med. 64(9),609-615

National Institute for Occupational Safety and Health (NIOSH) (2009) Approaches to Safe Nanotechnology, managing the health and safety concerns associated with engineered nanomaterials. DHHS (NIOSH) Pub. No. 2009-125. Cincinnati, Ohio.

Nel, A., Grainger, D., Alvarez, P.J., et al., 2011. Nanotechnology environmental, health, and safety issues. In Nanotechnology Research Directions for Societal Needs in 2020. Springer (Netherlands), 2011

Nemmar, A., Hoet, P.M., Vanquickenborne, B., et al., 2002. Passage of inhaled particles into the blood circulation in humans. Circulation, 105(4),411-414.

Oberdörster, G., Ferin, J., Lehnert, B.E., 1994. Correlation between particle size, in vivo particle persistence, and lung injury. Environ. Health. Perspect. 102(5),173.

Oberdorster, G., Finkelstein, J., Ferin, J., et al., 1996. Ultrafine particles as a potential environmental health hazard. Studies with model particles. Chest. 109(3 Suppl.),68–69.

Oberdörster, G., 2000. Toxicology of ultrafine particles: in vivo studies. Physical and Engineering Sciences 358(1775), 2719-2740

Oberdörster, G., Sharp, Z., Atudorei, V., et al., 2002. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J. Toxicol. Environ. Health. A 65(20),1531-1543.

Oberdorster, G., Maynard, A., Donaldson, K., et al., 2005a Principles for characterizing the potential human health effects from exposure to nanomaterials: Elements of a screening strategy. Part Fibre Toxicol doi:10.1186/1743-8977-2-8.

Oberdoster, G., Oberdörster, E., Oberdörster, J., 2005b. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113,823-839.

OECD (2009) Emission assessment for the identification of sources and release of airborne manufactured nanomaterials in the workplace: compilation of existing guidance, ENV/JM/MONO, number 11, 2009

Peters, A., Wichmann, H., Tuch, T., et al., 1997. Respiratory effects are associated with the number of ultrafine particles. Am. J. Respir. Crit. Care. Med. 155,1376-1383

Pietroiusti, A., Magrini, A., 2014. Engineered nanoparticles at the workplace: current knowledge about workers’ risk. Occ. Med. 64(5), 319-330.

Price, H.D., Stahlmecke, B., Arthur, R., et al., 2014. Comparison of instruments for particle number size distribution measurements in air quality monitoring. J. Aerosol. Sci. 76, 48-55.

Read, S.A.K., Sanchez Jiménez, A., Ross, B.L., et al. Nanotechnology and Exposure Scenarios In Handbook of Nanosafety - Measurement, Exposure & Toxicology, Elsevier Academic Press, London (UK), 2014.

Regulation (EC) No 1272/2008 of the European Parliament and of the Council (CLP Regulation), OJ L 353, 31 December 2008.

Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 (REACh Regulation), OJ L 396, 30 December 2006.

Riediger, G., Möhlmann, C., 2001. Ultrafeine Aerosole an Arbeitsplätzen - Konventionen und Beispiele aus der Praxis. Gefahrstoffe – Reinhalt. Luft. 61,429-434

Roco, M.C., 2011. The long view of nanotechnology development: the National Nanotechnology Initiative at 10 years. J. Nanopart. Res. 13,427-445.

Sajid, M., Ilyas, M., Basheer, C., et al., 2015. Impact of nanoparticles on human and environment: review of toxicity factors, exposures, control strategies, and future prospects. Environ. Sci. Pollut. Res. Int. 22(6),4122-4143.

Schlesinger, R.B. Deposition and clearance of inhaled particle. In McClella RO and Henderson RF (eds): Concepts in Inhalation Toxicology, 2nd ed. CRC Press, London (UK), 1995

Schmoll, L.H., Peters, T.M., O'Shaughnessy, P.T., 2010. Use of a condensation particle counter and an optical particle counter to assess the number concentration of engineered nanoparticles. J. Occup. Environ. Hyg. 7(9), 535-545.

Schulte, P.A., et al., 2016 Assessing the protection of the nanomaterial workforce. Nanotoxicology doi: 10.3109/17435390.2015.1132347 (article in press).

Schulte, P.A., Schubauer-Berigan, M.K., Mayweather, C., Geraci, C.L., Zumwalde, R., McKernan, J.L., 2009. Issues in the development of epidemiologic studies of workers exposed to engineered nanoparticles. J. Occup. Environ. Med. 51(3),323-335.

Semmler, M. Sitz, J., Erbe, F., et al., 2004. Long-term clearance kinetics of inhaled ultrafine insoluble iridium particles from the rat lung, including transient translocation into secondary organs. Inhal. Toxicol. 16,453-459.

Sonavane, G., Tomoda, K., Sano, A., et al., 2008. In vitro permeation of gold nanoparticles through rat skin and rat intestine: Effect of particle size. Colloids. Surf. B 65, 1-10.

Stone, V., Hankin, S., Aitken, R. et al. Engineered Nanoparticles: Review of Health and Environmental Safety. Edinburgh Napier University. 2010 (21 October 2015, date last accessed).

Takenaka, S., Karg, E., Roth, C., et al., 2001. Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. Environ. Health. Perspect. 109(4), 547.

The American Conference of Governmental Industrial Hygienists. Threshold Limit Values for Chemical Substances and Physical Agents & Biological Exposure Indices. Cincinnati, OH: Signature Publications. 2010

Tinkle, S.S., Antonini, J.M., Rich, B.A., et al., 2003. Skin as a route of exposure and sensitization in chronic beryllium disease. Environ. Health. Perspect. 111, 1202-1208.

Tran, C.L., Buchanan, D., Cullen, R.T., et al., 2000. Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance. Inhal. Toxicol. 12(12), 1113-1126.

Van Broekhuizen, P., van Veelen, W., Streekstra, W.H., et al., 2012. Exposure limits for nanoparticles: report of an international workshop on nano reference values. Ann. Occup. Hyg. 56,515-524.

Wilson, W.E., 2004. Use of the electrical aerosol detector as an indicator for the total particle surface area deposited in the lung. Proceedings of the 2004 Air and Waste Management Association Conference.

Wittmaack, K., 2007. In search of the most relevant parameter for quantifying lung inflammatory response to nanoparticle exposure: particle number, surface area, or what? Environ. Health. Persp. 115(2), 187-194.

Woskie, S., Bello, D., Virji, M., et al., 2010. Understanding workplace processes and factors that influence exposures to engineered nanomaterials. Int. J. Occup. Environ. Health. 16,365-77.

Zhang, M., Jin, J., Chang, Y.N., Chang, X., Xing, G., 2014. Toxicological properties of nanomaterials. J. Nanosci. Nanotechnol. 14(1),717-729.

Zimmerman, N., Pollitt, K.J.G., Jeong, C.H., et al., 2014. Comparison of three nanoparticle sizing instruments: The influence of particle morphology. Atm. Environ. 86,140-147.


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